Cocarboxylase

Chemical Name:  
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)thiazolium chloride P,P'-dioxide
Synonyms: Thiamin Pyrophosphate Chloride (TPP)         
Molecular Formula: C12H19ClN4O7P2S     
Molecular Weight: 460.77
CAS RN: 154-87-0

The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.

Cocarboxylase and its hydrate, also known as thiamine pyrophosphate, is the coenzyme of decarboxylase and transketolase in carbohydrate metabolism. Cocarboxylase is involved in the oxidative decarboxylation of pyruvic acid and α-ketoglutaric acid in sugar metabolism. Cocarboxylase is a necessary substance in carbohydrate metabolism, which plays an important role in the complete oxidation and energy generation of carbohydrates. 

Insufficient formation of cocarboxylase will cause disturbance of carbohydrate metabolism and accumulation of intermediate metabolic products such as pyruvate and lactic acid in blood. This kind of metabolic disturbance will directly affect the function of heart and muscle tissue, and affect the energy supply of human body at the same time. The main symptoms of cocarboxylase deficiency are revealed on nervous system, cardiovascular system and digestive system. Clinically, cocarboxylase is often used in the treatment of beriberi and Wernicke encephalopathy, and cocarboxylase can also be used in the auxiliary treatment of peripheral neuritis and dyspepsia.